Procedure-Related Fetal Loss following Chorionic Villus Sampling after First-Trimester Aneuploidy Screening

Fetal Diagn Ther. 2017;41(3):184-190. doi: 10.1159/000447538. Epub 2016 Jul 12.


Objective: The aim was to determine the institutional procedure-related fetal loss rate after chorionic villus sampling (CVS) and the factors which may identify pregnancies at increased risk of having a procedure-related loss.

Materials and methods: Pregnancy outcomes were retrieved of all women having a singleton pregnancy and undergoing a CVS procedure between 2004 and 2013 at a university hospital in Hong Kong. The incidence of procedure-related fetal loss due to unintended miscarriages adjusted for the background loss incidence of miscarriages was determined. Multivariate regression was performed to examine the factors contributing to an unintended fetal loss and miscarriage.

Results: CVS was performed on 1,906 fetuses. The procedure-related fetal loss rate was 0.17% (95% CI -0.2 to 0.7). After multivariate analysis, a decreased plasma protein-A (PAPP-A) multiple of the median (OR 0.27; 95% CI 0.08-0.98, p = 0.046) was significantly associated with miscarriage in women who did not undergo a CVS. Patient-specific prediction of spontaneous abortion in women who did not undergo CVS was not statistically significant (AUC 0.56; 95% CI 0.49-0.6, p = 0.14).

Conclusions: The CVS-related fetal loss rate adjusted for background loss was 0.17%. Pregnancies with reduced PAPP-A carry an increased risk of miscarriage irrespective of whether they had undergone an invasive procedure.

Keywords: Chorionic villus sampling; Fetal loss; First-trimester Down syndrome screening; Miscarriage; Procedure-related risk.

MeSH terms

  • Abortion, Spontaneous / diagnosis
  • Abortion, Spontaneous / etiology*
  • Abortion, Spontaneous / genetics*
  • Adult
  • Aneuploidy*
  • Chorionic Villi Sampling / adverse effects*
  • Chorionic Villi Sampling / trends
  • Female
  • Follow-Up Studies
  • Humans
  • Pregnancy
  • Pregnancy Trimester, First / genetics*
  • Retrospective Studies
  • Risk Factors