The antioxidant effect of Green Tea Mega EGCG against electromagnetic radiation-induced oxidative stress in the hippocampus and striatum of rats

Electromagn Biol Med. 2017;36(1):63-73. doi: 10.1080/15368378.2016.1194292. Epub 2016 Jul 11.


Electromagnetic radiation (EMR) of cellular phones may affect biological systems by increasing free radicals and changing the antioxidant defense systems of tissues, eventually leading to oxidative stress. Green tea has recently attracted significant attention due to its health benefits in a variety of disorders, ranging from cancer to weight loss. Thus, the aim of the present study was to investigate the effect of EMR (frequency 900 MHz modulated at 217 Hz, power density 0.02 mW/cm2, SAR 1.245 W/kg) on different oxidative stress parameters in the hippocampus and striatum of adult rats. This study also extends to evaluate the therapeutic effect of green tea mega EGCG on the previous parameters in animals exposed to EMR after and during EMR exposure. The experimental animals were divided into four groups: EMR-exposed animals, animals treated with green tea mega EGCG after 2 months of EMR exposure, animals treated with green tea mega EGCG during EMR exposure and control animals. EMR exposure resulted in oxidative stress in the hippocampus and striatum as evident from the disturbances in oxidant and antioxidant parameters. Co-administration of green tea mega EGCG at the beginning of EMR exposure for 2 and 3 months had more beneficial effect against EMR-induced oxidative stress than oral administration of green tea mega EGCG after 2 months of exposure. This recommends the use of green tea before any stressor to attenuate the state of oxidative stress and stimulate the antioxidant mechanism of the brain.

Keywords: Electromagnetic radiation; green tea; hippocampus; oxidative stress; rat; striatum.

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • Electromagnetic Radiation*
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • Hippocampus / radiation effects
  • Male
  • Neostriatum / drug effects
  • Neostriatum / metabolism*
  • Neostriatum / radiation effects
  • Oxidative Stress / drug effects*
  • Oxidative Stress / radiation effects*
  • Rats
  • Rats, Wistar
  • Tea / chemistry*


  • Antioxidants
  • Tea
  • Catechin
  • epigallocatechin gallate