Biochemical and synthetic biology approaches to improve photosynthetic CO 2-fixation

Curr Opin Chem Biol. 2016 Oct;34:72-79. doi: 10.1016/j.cbpa.2016.06.026. Epub 2016 Jul 9.


There is an urgent need to improve agricultural productivity to secure future food and biofuel supply. Here, we summarize current approaches that aim at improving photosynthetic CO2-fixation. We critically review, compare and comment on the four major lines of research towards this aim, which focus on (i) improving RubisCO, the CO2-fixing enzyme in photosynthesis, (ii) implementing CO2-concentrating mechanisms, (iii) establishing synthetic photorespiration bypasses, and (iv) engineering synthetic CO2-fixation pathways.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Dioxide / metabolism*
  • Catalysis
  • Photosynthesis*
  • Ribulose-Bisphosphate Carboxylase / metabolism
  • Synthetic Biology*


  • Carbon Dioxide
  • Ribulose-Bisphosphate Carboxylase