Total Synthesis of the Illicium-Derived Sesquineolignan Simonsol C

Org Lett. 2016 Aug 5;18(15):3798-801. doi: 10.1021/acs.orglett.6b01799. Epub 2016 Jul 11.

Abstract

The racemic form of the title natural product 1 has been synthesized by engaging, as a key step, the iodoarene-tethered cyclohexene 22 in an intramolecular Heck reaction to give compound 23. This angularly substituted tetrahydrodibenzo[b,d]furan was elaborated over a further five steps into target (±)-1.

Publication types

  • Research Support, Non-U.S. Gov't