Herpes labialis treatment with acyclovir 5% modified aqueous cream: a double-blind randomized trial

Oral Surg Oral Med Oral Pathol. 1989 Jun;67(6):676-9. doi: 10.1016/0030-4220(89)90007-8.


The efficacy of 5% acyclovir in a modified aqueous cream vehicle (ACV-MAC) in the treatment of recurrent herpes labialis was tested in a randomized, double-blind clinical trial with the modified aqueous cream vehicle as a control medication. The ACV-MAC formulation has previously been shown to offer superior cutaneous absorption relative to other topical acyclovir formulations. Treatment was initiated by patients within 1 hour of prodrome in an attempt to maximize clinical impact of this virustatic drug. While the patient group receiving active drug showed a trend toward accelerated healing, no significant differences for lesion or healing characteristics could be measured between the two treatment groups. It is suggested that optimal efficacy of ACV-MAC may be predicated on prophylactic treatment, that is, "trigger"-initiated rather than prodrome-initiated treatment.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / adverse effects
  • Acyclovir / therapeutic use*
  • Adult
  • Double-Blind Method
  • Female
  • Herpes Labialis / drug therapy*
  • Humans
  • Male
  • Ointments
  • Random Allocation
  • Recurrence


  • Ointments
  • Acyclovir