Drugs That May Cause or Exacerbate Heart Failure: A Scientific Statement From the American Heart Association

Circulation. 2016 Aug 9;134(6):e32-69. doi: 10.1161/CIR.0000000000000426. Epub 2016 Jul 11.


Heart failure is a common, costly, and debilitating syndrome that is associated with a highly complex drug regimen, a large number of comorbidities, and a large and often disparate number of healthcare providers. All of these factors conspire to increase the risk of heart failure exacerbation by direct myocardial toxicity, drug-drug interactions, or both. This scientific statement is designed to serve as a comprehensive and accessible source of drugs that may cause or exacerbate heart failure to assist healthcare providers in improving the quality of care for these patients.

Keywords: AHA Scientific Statements; drug interactions; drug monitoring; drug therapy; drug-related adverse effects and adverse reactions; heart failure; nonprescription drugs.

Publication types

  • Review

MeSH terms

  • American Heart Association*
  • Heart Failure / chemically induced*
  • Heart Failure / diagnosis*
  • Heart Failure / epidemiology
  • Humans
  • Practice Guidelines as Topic / standards*
  • Prescription Drugs / adverse effects*
  • United States / epidemiology


  • Prescription Drugs