Time to move the fat

Genes Dev. 2016 Jul 1;30(13):1481-2. doi: 10.1101/gad.285460.116.


In this issue of Genes & Development, Dowen and colleagues (pp. 1515-1528) elegantly unify two previously unconnected aspects of physiology. The investigators provide significant genetic evidence to support a critical link between developmental timing decisions and the regulation of lipid mobilization at the transition to adulthood in Caenorhabditis elegans This novel connection involves cross-tissue signaling from the hypodermis (epidermis) to the intestine to promote reproductive success in the germline.

Keywords: fat metabolism; insulin; mTORC2; microRNAs; pqm-1; vitellogenesis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins / genetics*
  • Gene Expression Regulation, Developmental
  • Germ Cells
  • Intestines
  • Signal Transduction


  • Caenorhabditis elegans Proteins