Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner

J Cereb Blood Flow Metab. 2017 Apr;37(4):1435-1446. doi: 10.1177/0271678X16656200. Epub 2016 Jan 1.

Abstract

Positron emission tomography (PET) with 15O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function that is obtained invasively by sampling blood from an artery. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative 15O-PET imaging. We then compared hemodynamic PET imaging performed on a PET/MR hybrid scanner against a conventional PET only scanner. We demonstrated the proposed imaging-based technique was able to generate brain hemodynamic parameter measurements in strong agreement with the traditional arterial sampling based approach. We also demonstrated that quantitative 15O-PET imaging can be successfully implemented on a PET/MR hybrid scanner.

Keywords: Arterial input function; cerebral blood flow; cerebral metabolic rate of oxygen; positron emission tomography.

MeSH terms

  • Adolescent
  • Adult
  • Brain / blood supply
  • Brain / diagnostic imaging*
  • Cerebral Arteries / diagnostic imaging
  • Cerebral Arteries / physiology*
  • Cerebrovascular Circulation / physiology*
  • Cerebrovascular Disorders / diagnostic imaging
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Oxygen Radioisotopes
  • Positron Emission Tomography Computed Tomography / methods*
  • Young Adult

Substances

  • Oxygen Radioisotopes