Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review

Mycoses. 2016 Dec;59(12):746-750. doi: 10.1111/myc.12525. Epub 2016 Jul 12.

Abstract

The fungi Paecilomyces variotii is a potential pathogen in immunocompromised and immunocompetent patients. Their rare association with clinical disease results in scarce literature regarding susceptibility and treatment. Here, we discuss a case involving successful treatment of probable P. variotii pneumonia with posaconazole after treatment failure with voriconazole. The current literature related to antifungal susceptibility profiles, microbiological identification methods and clinical management of infections caused by this organism is also reviewed.

Keywords: Paecilomyces variotii; pneumonia; posaconazole.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antifungal Agents / therapeutic use*
  • Female
  • Humans
  • Middle Aged
  • Mycoses / diagnostic imaging
  • Mycoses / drug therapy*
  • Mycoses / microbiology
  • Paecilomyces / drug effects*
  • Paecilomyces / genetics
  • Paecilomyces / physiology
  • Pneumonia / diagnostic imaging
  • Pneumonia / drug therapy*
  • Pneumonia / microbiology
  • Triazoles / therapeutic use*

Substances

  • Antifungal Agents
  • Triazoles
  • posaconazole