Primary ovarian carcinoid: A report of two cases and a decade registry

J Egypt Natl Canc Inst. 2016 Dec;28(4):267-275. doi: 10.1016/j.jnci.2016.06.003. Epub 2016 Jul 9.


Objectives: This study aims at reporting 2 cases of primary ovarian carcinoid tumor, and providing an adequate registry of such cases and how they were managed.

Methods: 2 female patients with primary ovarian carcinoid were diagnosed and treated in our center. Discussion of their presentation, pathology and treatment is entitled. Also a thorough search of all published registries and case reports of ovarian carcinoid was done with analysis of reported data.

Results: 164 cases of primary ovarian carcinoid tumor were detected since 2005 with the predominance of the insular variant. Carcinoid syndrome occurs in nearly 14% of these cases. Most of the cases were treated with hysterectomy. Unfortunately, the prognosis was not documented in most series.

Conclusion: Primary ovarian carcinoid is a relatively rare disease with an indolent course and excellent outcome. Carcinoid syndrome, especially carcinoid heart disease may worsen the prognosis. Total abdominal hysterectomy with bilateral salpingo-oophorectomy has been commonly used as the treatment of choice of primary ovarian carcinoid tumors.

Keywords: Carcinoid heart; Carcinoid syndrome; Neuroendocrine tumors; Ovarian carcinoid; Registry; Transforming teratoma.

MeSH terms

  • Carcinoid Tumor / diagnosis
  • Carcinoid Tumor / pathology
  • Carcinoid Tumor / surgery*
  • Female
  • Humans
  • Hysterectomy
  • Middle Aged
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery*
  • Ovariectomy
  • Treatment Outcome