Diagnostic and prognostic significance of receptor-binding cancer antigen expressed on SiSo cells in lung-cancer-associated pleural effusion

Clin Respir J. 2018 Jan;12(1):279-284. doi: 10.1111/crj.12527. Epub 2016 Jul 21.

Abstract

Objectives: This study aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of soluble receptor-binding cancer antigen expressed on SiSo cells (sRCAS1) in lung cancer patients with malignant pleural effusion (MPE).

Methods: Pleural effusion samples were collected from 78 patients with MPE, and from 48 patients with benign pleural effusion (BPE). Pleural effusion sRCAS1 concentrations were measured by enzyme-linked immunosorbent assay.

Results: MPE has significantly higher sRCAS1 levels than that of BPE (P < .01). With a cutoff value of 18.7 U/mL, sRCAS1 showed a good diagnostic performance for MPE. Univariate and multivariate analysis indicated that elevated sRCAS1 levels were an independent predictor of overall survival (OS) and disease-free survival (DFS). Kaplan-Meier survival curves further confirmed that patients with high sRCAS1 have shorter DFS and OS (P = .026 and P = .032, respectively).

Conclusion: In conclusion, measurement of sRCAS1 might be a useful diagnostic and prognostic marker for MPE.

Keywords: diagnosis; lung cancer; pleural effusion; prognosis; sRCAS1.

MeSH terms

  • Adult
  • Aged
  • Antigens, Neoplasm / biosynthesis*
  • Biomarkers, Tumor / biosynthesis
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Lung Neoplasms / complications*
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / metabolism
  • Male
  • Middle Aged
  • Pleural Effusion, Malignant / diagnosis*
  • Pleural Effusion, Malignant / etiology
  • Pleural Effusion, Malignant / metabolism
  • Prognosis
  • Reproducibility of Results
  • Retrospective Studies

Substances

  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • EBAG9 protein, human