Germ Cells Need Folate to Proliferate

Dev Cell. 2016 Jul 11;38(1):8-9. doi: 10.1016/j.devcel.2016.06.022.

Abstract

In this issue of Developmental Cell, Chaudhari and colleagues (2016) use a novel method to create an in vitro proliferative cell line from tumorous C. elegans germ cells, and in the process discover that bacterial folates act as signals for proliferation, independent of their roles as vitamins.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / growth & development*
  • Caenorhabditis elegans / metabolism
  • Cell Proliferation*
  • Folic Acid / metabolism*
  • Germ Cells / cytology*
  • Germ Cells / metabolism

Substances

  • Folic Acid