The use of low-dose sodium valproate in the management of neuropathic pain: illustrative case series

Intern Med J. 2016 Jul;46(7):849-52. doi: 10.1111/imj.13125.

Abstract

Anti-epileptic drugs are commonly used in the management of neuropathic pain. Sodium valproate, however, is an anti-epileptic drug that is not commonly used. We report four patients with neuropathic pain who responded very well to the initiation of low-dose oral sodium valproate. Low-dose sodium valproate may have a role in managing neuropathic pain, especially when other first-line agents are unsuccessful or relatively contraindicated.

Keywords: neuralgia; pain; valproic acid.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anticonvulsants / administration & dosage*
  • Australia
  • Female
  • Humans
  • Middle Aged
  • Neuralgia / drug therapy*
  • Treatment Outcome
  • Valproic Acid / administration & dosage*

Substances

  • Anticonvulsants
  • Valproic Acid