Ibrutinib penetrates the blood brain barrier and shows efficacy in the therapy of Bing Neel syndrome

Br J Haematol. 2017 Oct;179(2):339-341. doi: 10.1111/bjh.14218. Epub 2016 Jul 13.

Authors

Christopher Mason¹, Steven Savona¹, Josephine N Rini^{2

3}, Jorge J Castillo⁴, Lian Xu⁴, Zachary R Hunter⁴, Steven P Treon⁴, Steven L Allen¹

Affiliations

¹ Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA.
² Hofstra Northwell School of Medicine, Lake Success, NY, USA.
³ Department of Radiology, Hofstra Northwell School of Medicine, Lake Success, NY, USA.
⁴ Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

PMID: 27409073
DOI: 10.1111/bjh.14218

No abstract available

Keywords: Bing Neel syndrome; CXCR4; MYD88; Waldenström macroglobulinemia; ibrutinib.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenine / analogs & derivatives
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / pharmacokinetics*
Biomarkers
Blood-Brain Barrier / metabolism*
Central Nervous System Neoplasms / diagnosis
Central Nervous System Neoplasms / drug therapy*
Central Nervous System Neoplasms / secondary*
Humans
Immunophenotyping
Magnetic Resonance Imaging
Male
Middle Aged
Piperidines
Positron Emission Tomography Computed Tomography
Protein Kinase Inhibitors / administration & dosage
Protein Kinase Inhibitors / pharmacokinetics*
Pyrazoles / administration & dosage
Pyrazoles / pharmacokinetics*
Pyrimidines / administration & dosage
Pyrimidines / pharmacokinetics*
Tomography, X-Ray Computed
Treatment Outcome
Waldenstrom Macroglobulinemia / complications*
Waldenstrom Macroglobulinemia / diagnosis
Waldenstrom Macroglobulinemia / drug therapy*

Substances

Antineoplastic Agents
Biomarkers
Piperidines
Protein Kinase Inhibitors
Pyrazoles
Pyrimidines
ibrutinib
Adenine