Microbially Produced Acetate: A "Missing Link" in Understanding Obesity?

Cell Metab. 2016 Jul 12;24(1):9-10. doi: 10.1016/j.cmet.2016.06.023.


Numerous studies have connected the gut microbiome with diet-induced obesity; however, mechanistic explanations for the host-microbial interactions are needed. Perry et al. (2016) present studies suggesting that microbially produced acetate (MPA) increases post-prandial insulin release via a sequential and integrated gut, brain, and pancreatic signaling network promoting energy retention.

Publication types

  • Comment

MeSH terms

  • Acetates
  • Diet
  • Energy Metabolism*
  • Gastrointestinal Tract*
  • Humans
  • Obesity


  • Acetates