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. 2016 Jul 12;24(1):75-90.
doi: 10.1016/j.cmet.2016.06.010.

Sucralose Promotes Food Intake Through NPY and a Neuronal Fasting Response

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Sucralose Promotes Food Intake Through NPY and a Neuronal Fasting Response

Qiao-Ping Wang et al. Cell Metab. .

Abstract

Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception, and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together, our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat.

Comment in

  • Sucralose Suppresses Food Intake.
    Park JH, Carvalho GB, Murphy KR, Ehrlich MR, Ja WW. Park JH, et al. Cell Metab. 2017 Mar 7;25(3):484-485. doi: 10.1016/j.cmet.2017.02.011. Cell Metab. 2017. PMID: 28273467 Free PMC article. No abstract available.

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