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. 2016 Jul 11;30(1):9-10.
doi: 10.1016/j.ccell.2016.06.018.

Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H)

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Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H)

Tim D D Somerville et al. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A(R882H)/NRAS(G12D) acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.

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