Semax prevents learning and memory inhibition by heavy metals

Dokl Biol Sci. 2016 May;468(1):112-4. doi: 10.1134/S0012496616030066. Epub 2016 Jul 14.

Abstract

Separate and joint effect of Semax, ascorbic acid, lead diacetate, and ammonium molybdate on avoidance conditioning in rats was studied. It was established that the heavy metal salts inhibited the avoidance response, and the peptide counteracted this inhibition as strongly as ascorbic acid or to a comparable degree. These findings confirm the antioxidant properties of Semax.

MeSH terms

  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Adrenocorticotropic Hormone / pharmacology
  • Animals
  • Antioxidants / pharmacology*
  • Avoidance Learning / drug effects*
  • Male
  • Memory / drug effects*
  • Molybdenum / toxicity*
  • Organometallic Compounds / toxicity*
  • Peptide Fragments / pharmacology*
  • Rats

Substances

  • Antioxidants
  • Organometallic Compounds
  • Peptide Fragments
  • ACTH (4-7), Pro-Gly-Pro-
  • Molybdenum
  • Adrenocorticotropic Hormone
  • ammonium molybdate
  • lead acetate