Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases

Cancer Invest. 2016 Aug 8;34(7):348-54. doi: 10.1080/07357907.2016.1197235. Epub 2016 Jul 14.

Abstract

Aim: To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy.

Materials and methods: Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis.

Results: The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity.

Conclusions: The treatment provided adequate clinical response in the management of oligometastatic cases.

Keywords: Abdominal metastases; RapidArc; flattening filter-free beams; volumetric-modulated arc therapy.

MeSH terms

  • Abdominal Neoplasms / diagnosis
  • Abdominal Neoplasms / mortality
  • Abdominal Neoplasms / radiotherapy*
  • Abdominal Neoplasms / secondary*
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Lymph Nodes / pathology*
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Pelvic Neoplasms / diagnosis
  • Pelvic Neoplasms / mortality
  • Pelvic Neoplasms / radiotherapy*
  • Pelvic Neoplasms / secondary*
  • Photons
  • Positron-Emission Tomography
  • Radiometry
  • Radiosurgery* / adverse effects
  • Radiosurgery* / methods
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy, Intensity-Modulated* / adverse effects
  • Radiotherapy, Intensity-Modulated* / methods
  • Tomography, X-Ray Computed
  • Treatment Outcome