Spontaneous repigmentation of silvery hair in an infant with congenital hydrops fetalis and hypoproteinemia

Cutis. 2016 Jun;97(6):E1-5.


Silvery hair is a characteristic finding of 3 rare autosomal recessive disorders: Chédiak-Higashi syndrome (CHS), Elejalde syndrome (ES), and Griscelli syndrome (GS). We report the case of a 2-month-old male infant with transient silvery hair and generalized hypopigmentation of the skin and eyes who did not have one of these classic causative disorders. The patient was delivered at 35 weeks' gestation with congenital hydrops fetalis associated with a chromosomal abnormality (46,XY,add[2],[p23]), hypothyroidism, hypoproteinemia, and hypogammaglobulinemia. Over the course of follow-up, spontaneous brown repigmentation of the silvery hair was noted. We concluded that the silvery hair was induced by hypoproteinemia secondary to congenital hydrops fetalis.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / complications
  • Chromosome Aberrations
  • Congenital Hypothyroidism / complications
  • Hair Diseases / complications
  • Hair Diseases / pathology*
  • Humans
  • Hydrops Fetalis
  • Hypopigmentation / complications
  • Hypopigmentation / pathology*
  • Hypoproteinemia / complications
  • Infant
  • Male
  • Remission, Spontaneous