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Review
. 2016 Jul;13(4):590-602.
doi: 10.3109/1547691X.2016.1149528. Epub 2016 Jul 14.

Anti-inflammatory and Immunomodulatory Properties of Carica Papaya

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Review

Anti-inflammatory and Immunomodulatory Properties of Carica Papaya

Saurabh Pandey et al. J Immunotoxicol. .

Abstract

Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords "papaya", "anti-inflammatory and inflammation" and "immunomodulation and immune" along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the anti-inflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking.

Keywords: Anti-inflammatory; Carica papaya; bioactivity; immunomodulatory; nutraceuticals.

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