[Efficacy and safety of dapoxetine in the treatment of premature ejaculation]

Zhonghua Nan Ke Xue. 2016 May;22(5):411-4.
[Article in Chinese]

Abstract

Objective: To evaluate the clinical effect and safety of dapoxetine in the treatment of premature ejaculation (PE).

Methods: We randomly assigned 116 PE patients to receive dapoxetine on demand at 30 mg qd (dapoxetine group, n = 60, aged 23-49 years) or oral tamsulosin at 20 mg qd (control group, n = 56, aged 24-46 years). After 4 weeks of medication, we compared the clinical global impression of change (CGIC) , PE profile (PEP) scores, intravaginal ejaculation latency time (IELT) , and adverse reactions between the two groups of patients.

Results: Compared with the baseline, the IELT was remarkably prolonged after treatment both in the dapoxetine group ([0.86 ± 0.17] vs [4.32 ± 2.23] min, P < 0.05) and the control ([0.88 ± 0.15] vs [4.17 ± 2.26] min, P < 0.05), with no statistically significant difference between the two groups (P > 0. 05). The post-treatment rate of CGIC in the dapoxetine group had no statistically significant difference from that in the control (85.00% vs 82.14%, P > 0.05). In comparison with pre-treatment, the patients of both the dapoxetine and control groups showed dramatically improved scores after medication in perceived control over ejaculation (0.85 ± 0.23 vs 2.13 ± 0.97 and 0.88 ± 0.21 vs 2.06 ± 0.34, both P < 0.05), ejaculation-related personal distress (1.15 ± 0.64 vs 2.89 ± 0.26 and 1.19 ± 0.53 vs 2.82 ± 0.69, both P < 0.05), satisfaction with sexual intercourse (0.81 ± 0.33 vs 2.58 ± 0.37 and 0.79 ± 0.28 vs 2.45 ± 0.32, both P < 0.05), and ejaculation-related interpersonal difficulty (2.05 ± 0.61 vs 3.24 ± 0.35 and 2.03 ± 0.65 vs 3.18 ± 0.76, both P < 0.05), with no significant differences between the two groups (P > 0.05). The incidence of adverse reactions was significantly lower in the dapoxetine than in the control group (3.33% vs 30.36%, P < 0.05).

Conclusion: Dapoxetine is effective for the treatment of PE, with its advantages of prolonging the intravaginal ejaculation latency time, improving the quality of sexual life, and low incidence of adverse reactions.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Benzylamines / administration & dosage*
  • Benzylamines / therapeutic use
  • Coitus
  • Double-Blind Method
  • Ejaculation
  • Humans
  • Male
  • Middle Aged
  • Naphthalenes / administration & dosage*
  • Naphthalenes / therapeutic use
  • Patient Satisfaction
  • Premature Ejaculation / drug therapy*
  • Selective Serotonin Reuptake Inhibitors / administration & dosage
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Sexual Behavior
  • Sulfonamides / administration & dosage
  • Sulfonamides / therapeutic use
  • Tamsulosin
  • Treatment Outcome
  • Young Adult

Substances

  • Benzylamines
  • Naphthalenes
  • Serotonin Uptake Inhibitors
  • Sulfonamides
  • Tamsulosin
  • dapoxetine