Abstract
It was investigated the effect of two adamantane derivatives, memantine and 5-hydroxyadamantan-2-one (5-HA), in patients with cerebrovascular disorders. In vitro studies showed that 5-HA, unlike memantine, exhibited antiplatelet activity. Experiments showed that memantine reduced cerebral blood flow in the brain cortex of intact rats and those under conditions of transient global ischemia, whereas 5-HA only selectively improved blood flow in ischemic brain and was superior to the reference drug nimodipine. The obtained data indicate the leading role of the GABA-ergic (rather than glutamatergic mechanisms) in implementation of the anti-ischemic cerebrovascular activity.
MeSH terms
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Adamantane / analogs & derivatives
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Adamantane / pharmacology*
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Adenosine Diphosphate / pharmacology
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Aged
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Animals
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Animals, Outbred Strains
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Blood Platelets / drug effects
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Cells, Cultured
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Cerebral Cortex / blood supply
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Cerebral Cortex / drug effects
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Cerebral Cortex / pathology
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Cerebrovascular Circulation / drug effects
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Epinephrine / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology*
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Female
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Humans
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Hypoxia-Ischemia, Brain / drug therapy*
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Hypoxia-Ischemia, Brain / pathology
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Ischemic Attack, Transient / drug therapy*
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Ischemic Attack, Transient / pathology
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Laser-Doppler Flowmetry
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Male
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Memantine / pharmacology*
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Middle Aged
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Nimodipine / pharmacology
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Platelet Aggregation / drug effects
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Rats
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Vasodilator Agents / pharmacology
Substances
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Excitatory Amino Acid Antagonists
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Vasodilator Agents
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Nimodipine
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Adenosine Diphosphate
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Adamantane
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Memantine
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Epinephrine