Spanish Validation of the Problem Behaviors Assessment-Short (PBA-s) for Huntington's Disease

J Neuropsychiatry Clin Neurosci. Winter 2017;29(1):31-38. doi: 10.1176/appi.neuropsych.16020025. Epub 2016 Jul 15.


A prospective, observational multicenter study was carried out assessing neuropsychiatric symptoms in a sample of 117 subjects in order to validate the Spanish version of the Problem Behaviors Assessment-Short (PBA-s). The psychometric properties of this version were analyzed. Inter- and intra-rater reliability were good: the mean weighted Cohen's kappa was 0.90 for severity scores and 0.93 for frequency scores. Four factors accounting for 56% of the total variance were identified after an exploratory factor analysis: apathy, irritability, depression, and perseveration. The PBA-s correlates strongly with the Neuropsychiatric Inventory, demonstrating its accuracy for assessing neuropsychiatric symptoms in patients with Huntington's disease.

Publication types

  • Multicenter Study
  • Observational Study
  • Validation Study

MeSH terms

  • Adult
  • Factor Analysis, Statistical
  • Female
  • Humans
  • Huntington Disease / diagnosis*
  • Huntington Disease / drug therapy
  • Huntington Disease / genetics
  • Huntington Disease / psychology*
  • Interview, Psychological
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Observer Variation
  • Problem Behavior*
  • Prospective Studies
  • Psychiatric Status Rating Scales*
  • Psychometrics
  • Translating