WT1 Mutation in Childhood Cancer

Methods Mol Biol. 2016;1467:1-14. doi: 10.1007/978-1-4939-4023-3_1.

Abstract

In this chapter, the role of WT1 in childhood cancer is discussed, using the key examples Wilms' tumor, desmoplastic small round cell of childhood, and leukemia. The role of WT1 in each disease is described and mirrored to the role of WT1 in normal development.

Keywords: Childhood cancer; Desmoplastic small round cell tumor of childhood; Development; Leukemia; Minimal residual disease; Wilms’ tumor.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Desmoplastic Small Round Cell Tumor / genetics*
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kidney / growth & development
  • Leukemia / genetics*
  • Mutation
  • WT1 Proteins / genetics*
  • Wilms Tumor / genetics*

Substances

  • WT1 Proteins
  • WT1 protein, human