WT1 Mutation in Childhood Cancer

Jocelyn Charlton; Kathy Pritchard-Jones

doi:10.1007/978-1-4939-4023-3_1

WT1 Mutation in Childhood Cancer

Methods Mol Biol. 2016;1467:1-14. doi: 10.1007/978-1-4939-4023-3_1.

Authors

Jocelyn Charlton¹, Kathy Pritchard-Jones^{2

3}

Affiliations

¹ UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
² UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. k.pritchard-jones@ucl.ac.uk.
³ Hugh and Catherine Stevenson Professor of Paediatric Oncology, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. k.pritchard-jones@ucl.ac.uk.

PMID: 27417955
DOI: 10.1007/978-1-4939-4023-3_1

Abstract

In this chapter, the role of WT1 in childhood cancer is discussed, using the key examples Wilms' tumor, desmoplastic small round cell of childhood, and leukemia. The role of WT1 in each disease is described and mirrored to the role of WT1 in normal development.

Keywords: Childhood cancer; Desmoplastic small round cell tumor of childhood; Development; Leukemia; Minimal residual disease; Wilms’ tumor.

MeSH terms

Adolescent
Child
Child, Preschool
Desmoplastic Small Round Cell Tumor / genetics*
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
Humans
Kidney / growth & development
Leukemia / genetics*
Mutation
WT1 Proteins / genetics*
Wilms Tumor / genetics*

Substances

WT1 Proteins
WT1 protein, human