Mendelian randomization in (epi)genetic epidemiology: an effective tool to be handled with care

Antti Latvala; Miina Ollikainen

doi:10.1186/s13059-016-1018-9

Mendelian randomization in (epi)genetic epidemiology: an effective tool to be handled with care

Genome Biol. 2016 Jul 14;17(1):156. doi: 10.1186/s13059-016-1018-9.

Authors

Antti Latvala¹, Miina Ollikainen^{2

3}

Affiliations

¹ Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00290, Helsinki, Finland.
² Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, 00290, Helsinki, Finland. miina.ollikainen@helsinki.fi.
³ Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00290, Helsinki, Finland. miina.ollikainen@helsinki.fi.

Abstract

A study examining blood lipid traits takes epigenomics approaches to the next level by using carefully performed Mendelian randomization to assess causality rather than simply reporting associations.See related research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1000-6.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Epigenesis, Genetic / genetics*
Humans
Lipids / blood
Lipids / genetics*
Molecular Epidemiology*
Phenotype
Random Allocation

Substances

Lipids