Antifungal effects of the biological agent Pythium oligandrum observed in vitro

J Feline Med Surg. 2017 Aug;19(8):817-823. doi: 10.1177/1098612X16658690. Epub 2016 Jul 1.


Objectives Dermatophytosis, commonly known as ringworm, is a superficial fungal skin disease and zoonosis. Pythium oligandrum is a micromycete with mycoparasitic properties that is used in agriculture to control fungal infections on plants. Formulations containing P oligandrum were also developed for the treatment of dermatophytoses, but only a small number of case studies have been published. In order to document the process in simplified conditions in vitro, we investigated the effectiveness of P oligandrum against three pathogenic dermatophytes common in domestic animals. Methods Cultures of the pathogens grown on nutrient media and experimentally infected cat hair were treated with P oligandrum preparations in therapeutic concentration and the changes were documented by microscopic videos and scanning electron microscopy. Results There was strong mycoparasitic activity of P oligandrum against Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes. Conclusions and relevance P oligandrum was demonstrated to be effective against three common causes of dermatophytosis in vitro.

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology*
  • Cat Diseases / drug therapy*
  • Cat Diseases / microbiology
  • Cats
  • Hair / microbiology
  • Microsporum / drug effects*
  • Parasitic Sensitivity Tests / veterinary
  • Pythium*
  • Tinea / drug therapy
  • Tinea / microbiology
  • Tinea / veterinary*
  • Treatment Outcome
  • Trichophyton / drug effects*


  • Antifungal Agents