Zika Virus Infection Associated With Severe Thrombocytopenia

Clin Infect Dis. 2016 Nov 1;63(9):1198-1201. doi: 10.1093/cid/ciw476. Epub 2016 Jul 14.


We report two patients that developed severe thrombocytopenia after Zika virus (ZIKV) infection. The first patient had 1000 platelets/μL and died after multiple hemorrhages. The second patient had 2000 platelets/μL, had melena and ecchymoses, and recovered after receiving intravenous immunoglobulin. ZIKV may be associated with immune-mediated severe thrombocytopenia.

Keywords: Puerto Rico; Zika virus; fatal; thrombocytopenia.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Humans
  • Immunoglobulins, Intravenous
  • Male
  • Thrombocytopenia / therapy
  • Thrombocytopenia / virology*
  • Treatment Outcome
  • Zika Virus Infection / physiopathology*
  • Zika Virus Infection / therapy


  • Immunoglobulins, Intravenous