Mammary Development and Breast Cancer: A Wnt Perspective

Cancers (Basel). 2016 Jul 13;8(7):65. doi: 10.3390/cancers8070065.


The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. In this review, we will summarize the current knowledge of how the pathway regulates stem cells and normal development of the mammary gland, and discuss how its various components contribute to breast carcinoma pathology.

Keywords: Wnt; breast cancer; development; mammary gland; stem cells.

Publication types

  • Review