Impaired colour vision in workers exposed to organic solvents: A systematic review

Arch Soc Esp Oftalmol. 2017 Jan;92(1):12-18. doi: 10.1016/j.oftal.2016.05.008. Epub 2016 Jul 13.
[Article in English, Spanish]


Objective: To evaluate recent evidence concerning the relationship between the exposure to organic solvents and the impairment of colour vision.

Methods: A bibliographic search was conducted for scientific papers published in the last 15 years, in the LILACS, PubMed, Science Direct, EBSCO, and Cochrane databases that included observational studies assessing the relationship between impairment in colour vision and exposure to organic solvents.

Results: Eleven studies were selected that were performed on an economically active population and used the Lanthony D-15 desaturated test (D-15d), measured the exposure to organic solvents, and included unexposed controls. It was found that there is a statistically significant relationship between the exposure to organic solvents and the presence of an impairment in colour vision.

Conclusions: The results support the hypothesis that exposure to organic solvents could induce acquired dyschromatopsia. The evaluation of colour vision with the D-15d test is simple and sensitive for diagnosis. More studies need to be conducted on this subject in order to better understand the relationship between impaired colour vision and more severe side effects caused by this exposure.

Keywords: Colour vision; Discromatopsia; Dyschromatopsia; Exposición ocupacional; Lanthony D-15; Occupational exposure; Puesto de trabajo; Solventes; Solvents; Visión de colores; Workplace.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Air Pollutants, Occupational / analysis
  • Air Pollutants, Occupational / toxicity
  • Color Perception Tests
  • Color Vision Defects / chemically induced*
  • Color Vision Defects / diagnosis
  • Humans
  • Meta-Analysis as Topic
  • Observational Studies as Topic
  • Occupational Diseases / chemically induced*
  • Occupational Exposure
  • Organic Chemicals / analysis
  • Organic Chemicals / toxicity*
  • Solvents / analysis
  • Solvents / toxicity*


  • Air Pollutants, Occupational
  • Organic Chemicals
  • Solvents