Comparison of the effect of atropine and cyclopentolate on myopia

Ann Ophthalmol. 1989 May;21(5):180-2, 187.


We evaluated the effectiveness of cycloplegics in the treatment of myopia. Patients were selected randomly and divided into three groups: Group 1 received atropine 1% eye drops every other night; Group 2 received cyclopentolate 1% eye drops every night; and Group 3 received normal saline eye drops every night. All the patients were rechecked every three months. The results were evaluated at the end of one year. Ninety-six patients were evaluated, 32 in each group. The mean myopic progression was -0.219 D in the atropine group, -0.578D in the cyclopentolate group, and -0.914D in the saline group. Analysis showed that atropine and cyclopentolate are effective in slowing the progression of myopia. The effect of atropine is better than that of cyclopentolate.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Atropine / therapeutic use*
  • Child
  • Cyclopentolate / therapeutic use*
  • Drug Evaluation
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Myopia / drug therapy*
  • Phenylacetates / therapeutic use*
  • Random Allocation
  • Refractive Errors / drug therapy
  • Time Factors


  • Phenylacetates
  • Atropine
  • Cyclopentolate