Outgroups and Positive Selection: The Nothobranchius furzeri Case

Trends Genet. 2016 Sep;32(9):523-525. doi: 10.1016/j.tig.2016.06.002. Epub 2016 Jul 13.


Applications of positive selection analysis increase with the number of species for which genome/transcriptome sequences become available. Using the recently sequenced turquoise killifish (Nothobranchius furzeri) genome as an example, we compare two different approaches based on different outgroup selection. The combination of these two methods allows the origin of positively selected sites in aging-related genes of the N. furzeri genome to be determined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Fundulidae / genetics*
  • Genome
  • Phylogeny*
  • Selection, Genetic / genetics*
  • Transcriptome / genetics*