[Hereditary haemorrhagic telangiectasia: importance of a multidisciplinary approach]

Rev Med Suisse. 2016 May 25;12(520):1056-8, 1060-2.
[Article in French]


The Rendu-Osler-Weber disease, also known as hereditary haemorrhagic telangiectasia, is an autosomal dominant inherited disease. Its main manifestations are nosebleeds and digestive tract bleeding due to angiodysplasia. The presence of arteriovenous malformations in organs such as lung, liver, brain, etc. can cause serious complications (haemorrhage, stroke, brain abscess, hypoxemia, increased cardiac output, pulmonary arterial hypertension). Diagnosis is based on clinical criteria and can be confirmed by genetic analysis. The prevalence of this rare disease is 1/5,000 to 1/10,000 and its expression varies widely, even in the same family. The management must be multidisciplinary and based on prevention and treatment of bleeding complications as well as screening and treatment of arteriovenous malformations.

Publication types

  • English Abstract

MeSH terms

  • Arteriovenous Malformations / etiology
  • Arteriovenous Malformations / therapy*
  • Hemorrhage / etiology
  • Hemorrhage / therapy*
  • Humans
  • Interdisciplinary Communication
  • Prevalence
  • Telangiectasia, Hereditary Hemorrhagic / diagnosis
  • Telangiectasia, Hereditary Hemorrhagic / physiopathology
  • Telangiectasia, Hereditary Hemorrhagic / therapy*