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, 161 (3), 1135-43

Age-dependent Decrease of Carnitine Content in Muscle of Mice and Humans

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Age-dependent Decrease of Carnitine Content in Muscle of Mice and Humans

M Costell et al. Biochem Biophys Res Commun.

Abstract

Carnitine deficiency associated with impairment of muscle function has been described in infants and young adults as a result of inherited or acquired disease but there are no reports on carnitine levels in healthy aging people. In this paper we show a marked reduction of carnitine and its derivatives in muscle, and of long-chain acyl carnitine in heart of 6-month-old mice, when compared to animals of 6 weeks of age. Analysis of muscle samples of healthy humans of different ages showed a drastic reduction of carnitine and acetyl carnitine in the older subjects with a strong reverse correlation between age and carnitine levels.

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