T-cell/histiocyte-rich large B-cell lymphoma of stomach

J Pak Med Assoc. 2016 Jul;66(7):905-7.


T-cell/histiocyte-rich large B-cell lymphoma is an unusually encountered lymphoid neoplasm of stomach with aggressive course, and is an uncommon morphologic variant of diffuse large B-cell lymphoma. An ulcerated mass, 7x5x1 cm in size was observed within the gastrectomy specimen of a 76-year-old female patient. In cross sections, besides mature lymphoid cells displaying T-cell phenotype, a neoplastic formation composed of large, pleomorphic atypical lymphoid cells with, prominent nucleoli, vesicular nuclei and abundant eosinophilic cytoplasm displaying B-cell phenotype were observed. Meanwhile, histiocyte-like mononuclear cells and Reed-Sternberg-like multinuclear cells expressing CD68 and Mac387 were also observed. The diagnosis of the case was T cell/histiocyte-rich large B-cell lymphoma. This rarely encountered neoplasm should be kept in mind in the differential diagnosis of primary gastric lymphomas.

Keywords: T-cell/histiocyte-rich large B-cell lymphoma; diffuse large B-cell lymphoma; gastric malignancies..

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Female
  • Gastrectomy / methods*
  • Histiocytes / pathology*
  • Humans
  • Immunohistochemistry
  • Lymphoma, Large B-Cell, Diffuse* / diagnosis
  • Lymphoma, Large B-Cell, Diffuse* / pathology
  • Lymphoma, Large B-Cell, Diffuse* / surgery
  • Neoplasm Staging
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / pathology
  • Stomach Neoplasms* / surgery
  • Stomach* / pathology
  • Stomach* / surgery
  • T-Lymphocytes / pathology*