Lasting hepatotoxic effects of prenatal mobile phone exposure

J Matern Fetal Neonatal Med. 2017 Jun;30(11):1355-1359. doi: 10.1080/14767058.2016.1214124. Epub 2016 Aug 10.


Objective: In this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes.

Methods: Pregnant rats were exposed to radiation (900 MHz EMF, 24 h/day for 20 days) using a digital signal generator by placing the device centrally under the cage, which formed the study (EMF) group, while untreated matching rats served as controls. Livers and blood were obtained from litters (seven males and seven females) of both groups 60 days after birth, which were used for biochemical and histopathological analyses.

Results: There was a significant increase in the levels of malondialdehyde (MDA) (p < 0.05) that was accompanied by a significant fall in glutathione (GSH) (p < 0.01) in the liver. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly increased (p < 0.05). Histopathologically, the liver sections of the EMF group showed intense degeneration in hepatocytes with cytoplasmic eosinophilic structures, pyknotic nuclei and fibrosis.

Conclusion: We demonstrate that the intrauterin harmful effects of EMF on the livers of rats persist into adulthood.

Keywords: Mobile phone radiation; electromagnetic field; liver toxicity; prenatal exposure.

MeSH terms

  • Alanine Transaminase / blood
  • Analysis of Variance
  • Animals
  • Aspartate Aminotransferases / blood
  • Cell Phone*
  • Electromagnetic Fields / adverse effects*
  • Female
  • Glutathione / analysis
  • Liver / pathology
  • Liver / radiation effects*
  • Male
  • Malondialdehyde / analysis
  • Maternal Exposure / adverse effects*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / etiology
  • Rats
  • Rats, Sprague-Dawley


  • Malondialdehyde
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Glutathione