Synthesis and quality control of [(18) F]T807 for tau PET imaging

J Labelled Comp Radiopharm. 2016 Aug;59(10):411-5. doi: 10.1002/jlcr.3425. Epub 2016 Jul 17.


The detailed synthesis and quality control of [(18) F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end-of-synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radiochemical yield of 32%. Compliance with all standard US Pharmacopeia Chapter <823> acceptance tests was observed.

Keywords: PET; fluorine-18; microwave; quality control; tau.

MeSH terms

  • Carbolines / chemical synthesis*
  • Carbolines / chemistry
  • Chemistry Techniques, Synthetic
  • Positron-Emission Tomography / methods*
  • Quality Control
  • Radiochemistry
  • tau Proteins / metabolism*


  • Carbolines
  • tau Proteins
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole