Synthesis and quality control of [(18) F]T807 for tau PET imaging

Daniel P Holt; Hayden T Ravert; Robert F Dannals

doi:10.1002/jlcr.3425

Synthesis and quality control of [(18) F]T807 for tau PET imaging

J Labelled Comp Radiopharm. 2016 Aug;59(10):411-5. doi: 10.1002/jlcr.3425. Epub 2016 Jul 17.

Authors

Daniel P Holt¹, Hayden T Ravert¹, Robert F Dannals¹

Affiliation

¹ Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

PMID: 27427174
DOI: 10.1002/jlcr.3425

Abstract

The detailed synthesis and quality control of [(18) F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end-of-synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radiochemical yield of 32%. Compliance with all standard US Pharmacopeia Chapter <823> acceptance tests was observed.

Keywords: PET; fluorine-18; microwave; quality control; tau.

MeSH terms

Carbolines / chemical synthesis*
Carbolines / chemistry
Chemistry Techniques, Synthetic
Positron-Emission Tomography / methods*
Quality Control
Radiochemistry
tau Proteins / metabolism*

Substances

Carbolines
tau Proteins
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole