Comparison of polyvinyl alcohol and tris-acryl gelatin microsphere materials in embolization for symptomatic leiomyomas: a systematic review

Minim Invasive Ther Allied Technol. 2016 Dec;25(6):289-300. doi: 10.1080/13645706.2016.1207667. Epub 2016 Jul 19.


Objective: Use systematic reviews and meta-analyses to assess the effect of polyvinyl alcohol and tris-acryl gelatin microsphere materials in leiomyoma embolization for symptomatic leiomyomas.

Material and methods: We included randomised controlled studies published before January 2015 comparing polyvinyl alcohol and tris-acryl gelatin microsphere materials in uterine leiomyoma embolization for women with symptomatic leiomyomas. The main outcome measures included change of overall quality of life, change of overall symptom severity, changes of uterine and leiomyoma volumes, leiomyoma infarction rate, treatment failure and complications.

Results: A total of six randomized controlled studies from 335 studies accounting for 351 women with leiomyomas were identified in this meta-analysis. Compared to polyvinyl alcohol, tris-acryl gelatin microsphere showed a significant benefit in improving the overall quality of life and in reducing uterine volume at three and six months, in reducing overall symptom severity at 6 and 12 months, and furthermore in reducing treatment failure. In addition, tris-acryl gelatin microsphere could significantly reduce leiomyoma volume and decrease <90% complete leiomyoma infarction rate at three months. There were no differences in pain severity, other post-procedural symptoms or medication use in the two groups.

Conclusions: A better effect of tris-acryl gelatin microsphere in leiomyoma embolization for patients with symptomatic leiomyoma.

Keywords: Polyvinyl alcohol; meta-analysis; symptomatic leiomyoma; tris-acryl gelatin microsphere.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Acrylic Resins / administration & dosage
  • Acrylic Resins / adverse effects
  • Acrylic Resins / chemistry*
  • Embolization, Therapeutic / methods*
  • Female
  • Gelatin / administration & dosage
  • Gelatin / adverse effects
  • Gelatin / chemistry*
  • Humans
  • Leiomyoma / therapy*
  • Microspheres*
  • Polyvinyl Alcohol / administration & dosage
  • Polyvinyl Alcohol / adverse effects
  • Polyvinyl Alcohol / chemistry*
  • Quality of Life
  • Randomized Controlled Trials as Topic
  • Severity of Illness Index
  • Tumor Burden
  • Uterine Neoplasms / therapy*
  • Uterus / anatomy & histology


  • Acrylic Resins
  • trisacryl gelatin microspheres
  • Gelatin
  • Polyvinyl Alcohol