A dRAStic RHOAdblock of Pyrin inflammasome activation

Nat Immunol. 2016 Jul 19;17(8):900-2. doi: 10.1038/ni.3511.

Abstract

The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised, in response to defects in the mevalonate pathway and directly by mutations in Pyrin, resulting in the IL-1β-driven autoinflammatory diseases MKD and FMF.

Publication types

  • Comment

MeSH terms

  • Carrier Proteins
  • Caspase 1
  • Inflammasomes*
  • Interleukin-1beta
  • Pyrin*

Substances

  • Carrier Proteins
  • Inflammasomes
  • Interleukin-1beta
  • Pyrin
  • Caspase 1