Imaging enzyme kinetics at atomic resolution

IUCrJ. 2016 Jun 27;3(Pt 4):228-9. doi: 10.1107/S2052252516010204. eCollection 2016 Jul 1.


Serial crystallography at a synchrotron has been used to obtain time-resolved atomic resolution density maps of enzyme catalysis in copper nitrite reductase. Similar XFEL studies, intended to out-run radiation damage, will also soon appear.

Keywords: catalysis; denitrification; enzyme mechanism; radiation damage; radiolysis; serial crystallography; synchrotron radiation.