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Editorial
. 2016 Jul 1;1(4):384-6.
doi: 10.1001/jamacardio.2016.0582.

Association of Atrial Fibrillation and Cancer

Faisal Rahman  1 , Darae Ko  1 , Emelia J Benjamin  2
Affiliations
Editorial

Association of Atrial Fibrillation and Cancer

Faisal Rahman et al. JAMA Cardiol. .
No abstract available

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Figures

Figure 1
Figure 1. Possible components underlying the association between atrial fibrillation and cancer
The factors contributing to the development, diagnosis, treatment, and complications of atrial fibrillation (AF) and cancer have complex interrelations, many of which are bidirectional. The development of AF and cancer are promoted by genetics, risk factors, systemic inflammation, and neurohormonal changes. Patient specific factors affect the likelihood of both conditions’ diagnosis. AF and cancer may in turn modify patient specific factors, the original risk factors, neurohormonal systems, and systemic inflammation. AF treatment is associated with increased healthcare exposure such as INR monitoring, follow-up outpatient visits, and increased risk of bleeding, which may hasten cancer diagnosis. Cancer treatments may also promote AF. Both AF and cancer can lead to multiple complications, which can further modify healthcare exposure, the original risk factors, systemic inflammation, and neurohormonal systems. The mechanisms underlying the bidirectional relations AF and cancer are incompletely understood and require further research.
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References

    1. Chugh SS, Havmoeller R, Narayanan K, et al. Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study. Circulation. 2014;129(8):837–847. - PMC - PubMed
    1. Rahman F, Kwan GF, Benjamin EJ. Global epidemiology of atrial fibrillation. Nat Rev Cardiol. 2014;11(11):639–654. - PubMed
    1. Soliman EZ, Safford MM, Muntner P, et al. Atrial fibrillation and the risk of myocardial infarction. JAMA internal medicine. 2014;174(1):107–114. - PMC - PubMed
    1. Schnabel RB, Rienstra M, Sullivan LM, et al. Risk assessment for incident heart failure in individuals with atrial fibrillation. Eur J Heart Fail. 2013;15(8):843–849. - PMC - PubMed
    1. Kalantarian S, Stern TA, Mansour M, Ruskin JN. Cognitive impairment associated with atrial fibrillation: a meta-analysis. Ann Intern Med. 2013;158(5 Pt 1):338–346. - PMC - PubMed