The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas

Turk Neurosurg. 2016;26(5):678-83. doi: 10.5137/1019-5149.JTN.12807-14.1.


Aim: To analyse the effect of MMP-3 (Matrix Metalloproteinase Enzyme-3)-one of the extracellular matrix proteins- on the prognosis and biological behaviour of meningiomas.

Material and methods: 79 cases of meningioma that were operated in our clinic between 2005 and 2010 were retrospectively analysed. Age, sex, preoperative peritumoral edema, histological subtype, grade, Ki-67 expression, MMP-3 staining pattern and recurrence rate were analysed. Pathological preparations were graded according to the WHO (World Health Organisation) 2007 grading system.

Results: Of the MMP-III positive cases; 24 cases (60%) were grade I, 16 cases were grade II. The MMP-3 staining pattern was significantly positive (80%) in grade II meningioma. 14 of the MMP-3 positive cases were atypical meningiomas. Of the 20 cases with high Ki-67 proliferation index (PI), 12 cases (60%) were MMP-3 positive and 8 cases (40%) were MMP-3 negative. Rates of recurrence and preoperative peritumoral edema were high in cases with MMP-3 positivity.

Conclusion: In this study it was determined that MMP-3 positivity has a strong relationship with meningiomas having an aggressive character. MMP-3 may be used as a proliferation marker for biological behaviour, recurrence rate and prognosis of meningiomas.

MeSH terms

  • Adult
  • Aged
  • Brain Neoplasms / complications
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / surgery
  • Edema / complications
  • Edema / pathology
  • Female
  • Humans
  • Ki-67 Antigen / biosynthesis
  • Male
  • Matrix Metalloproteinase 3 / metabolism*
  • Meningeal Neoplasms / complications
  • Meningeal Neoplasms / metabolism*
  • Meningeal Neoplasms / pathology*
  • Meningioma / complications
  • Meningioma / metabolism*
  • Meningioma / pathology*
  • Meningioma / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prognosis
  • Retrospective Studies
  • Turkey


  • Ki-67 Antigen
  • Matrix Metalloproteinase 3