Precocious pseudopuberty associated with multiple ovarian follicular cysts and low plasma oestradiol concentrations

Eur J Pediatr. 1989 Jun;148(7):600-2. doi: 10.1007/BF00441508.


A 6 year 11 month old girl had pseudoprecocious puberty caused by multiple ovarian follicular cysts. In contrast to previously reported patients, oestrogen levels in blood and urine were not elevated though gonadotropins were suppressed. Despite the lack of measurable oestrogen elevation the child developed distinct oestrogenic effects. After removal of large bilateral ovarian cysts endocrine aberrations normalized and precocity regressed.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Estradiol / blood*
  • Female
  • Follicular Cyst / complications*
  • Follicular Cyst / pathology
  • Humans
  • Ovarian Cysts / complications*
  • Ovarian Cysts / pathology
  • Puberty, Precocious / etiology*


  • Estradiol