Tumour necrosis factor in neonatal listeriosis: a case report

Eur J Pediatr. 1989 Jun;148(7):644-5. doi: 10.1007/BF00441521.


A newborn with fatal neonatal listeriosis developed septic shock, neutropenia, thrombocytopenia and profound hypoxaemia due to severe pulmonary hypertension. Tumour necrosis factor alpha, interleukin-1-beta and interferon-gamma serum concentrations were markedly elevated, suggesting the participation of these cytokines in the aetiopathogenesis of shock induced by Listeria monocytogenes in the neonate.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amoxicillin / therapeutic use
  • Gentamicins / therapeutic use
  • Humans
  • Hypertension, Pulmonary / etiology
  • Infant, Newborn
  • Listeriosis / blood*
  • Listeriosis / complications
  • Male
  • Shock, Septic / etiology*
  • Tumor Necrosis Factor-alpha / analysis*


  • Gentamicins
  • Tumor Necrosis Factor-alpha
  • Amoxicillin