Abstract
Gamma-aminobutyric acid (GABA) was shown to exert the immunodepressive effect. The use of GABA under induction of cytochrome P-450 of the liver by phenobarbital or rifampicin was not followed by immunodepression. The obtained data indicate the dependence of GABA pharmacological activity from the function of cytochrome P-450-dependent monooxygenase system of the liver.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Cytochrome P-450 Enzyme System / biosynthesis*
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Enzyme Induction / drug effects
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Erythrocytes / immunology
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Hexobarbital / pharmacology
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Immunization
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Immunosuppressive Agents*
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Liver / drug effects*
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Liver / enzymology
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Male
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Mice
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Phenobarbital / pharmacology
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Rifampin / pharmacology
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Sleep / drug effects
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gamma-Aminobutyric Acid / pharmacology*
Substances
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Immunosuppressive Agents
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gamma-Aminobutyric Acid
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Cytochrome P-450 Enzyme System
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Hexobarbital
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Rifampin
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Phenobarbital