Fungal skull base osteomyelitis: Emerging microbial identification techniques

Laryngoscope. 2017 Jan;127(1):E5-E7. doi: 10.1002/lary.25752. Epub 2016 Jul 22.


Culture-based pathogen identification in skull base osteomyelitis, particularly for fungi, is often inaccurate. We report the case of patient with fungal skull base osteomyelitis cured by sustained antifungal therapy after 16 months of debilitating illness. Due to medical complications, a strong clinical rationale was needed to justify long-term antifungal therapy. The offending fungus was identified by experimental molecular technology (Ibis T5000 universal biosensor); invasive fungal disease was corroborated by biochemical assays. Our discussion will help familiarize the otolaryngologist with existing biochemical and molecular diagnostics for invasive fungal disease. We encourage future investigators to study their application in cases of skull base osteomyelitis. Laryngoscope, 127:E5-E7, 2017.

Keywords: Cranial base; cranial base; molecular biology.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Aspergillosis / diagnosis*
  • Aspergillosis / drug therapy
  • Aspergillosis / microbiology*
  • Diagnosis, Differential
  • Diagnostic Imaging
  • Humans
  • Male
  • Middle Aged
  • Mycoses / diagnosis*
  • Mycoses / drug therapy
  • Mycoses / microbiology*
  • Osteomyelitis / diagnosis*
  • Osteomyelitis / drug therapy
  • Osteomyelitis / microbiology*
  • Skull Base / microbiology*


  • Antifungal Agents