Role of Magnesium in Oxidative Stress in Individuals with Obesity

Biol Trace Elem Res. 2017 Mar;176(1):20-26. doi: 10.1007/s12011-016-0793-1. Epub 2016 Jul 22.


Adipose tissue is considered an endocrine organ that promotes excessive production of reactive oxygen species when in excess, thus contributing to lipid peroxidation. Magnesium deficiency contributes to the development of oxidative stress in obese individuals, as this mineral plays a role as an antioxidant, participates as a cofactor of several enzymes, maintains cell membrane stability and mitigates the effects of oxidative stress. The objective of this review is to bring together updated information on the participation of magnesium in the oxidative stress present in obesity. We conducted a search of articles published in the PubMed, SciELO and LILACS databases, using the keywords 'magnesium', 'oxidative stress', 'malondialdehyde', 'superoxide dismutase', 'glutathione peroxidase', 'reactive oxygen species', 'inflammation' and 'obesity'. The studies show that obese subjects have low serum concentrations of magnesium, as well as high concentrations of oxidative stress marker in these individuals. Furthermore, it is evident that the adequate intake of magnesium contributes to its appropriate homeostasis in the body. Thus, this review of current research can help define the need for intervention with supplementation of this mineral for the prevention and treatment of disorders associated with this chronic disease.

Keywords: Glutathione peroxidase; Inflammation; Magnesium; Malondialdehyde; Obesity; Oxidative stress; Reactive oxygen species; Superoxide dismutase.

Publication types

  • Review

MeSH terms

  • Dietary Supplements
  • Humans
  • Lipid Peroxidation / drug effects
  • Magnesium / administration & dosage
  • Magnesium / metabolism
  • Magnesium / physiology*
  • Magnesium Deficiency / metabolism
  • Magnesium Deficiency / physiopathology*
  • Magnesium Deficiency / prevention & control
  • Malondialdehyde / metabolism
  • Models, Biological
  • Obesity / metabolism
  • Obesity / physiopathology*
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism


  • Reactive Oxygen Species
  • Malondialdehyde
  • Magnesium