Cobalt-catalyzed chelation assisted C-H allylation of aromatic amides with unactivated olefins

Chem Commun (Camb). 2016 Aug 9;52(66):10129-32. doi: 10.1039/c6cc05330k.

Abstract

The cobalt-catalyzed chelation assisted ortho C-H allylation of aromatic amides with unactivated aliphatic alkenes is reported. The reaction proceeds in air under mild reaction conditions, providing allylated products in good to excellent yields with high E-selectivities. This operationally simple method shows a high functional group tolerance.