The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

Ido Livneh; Victoria Cohen-Kaplan; Chen Cohen-Rosenzweig; Noa Avni; Aaron Ciechanover

doi:10.1038/cr.2016.86

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

Cell Res. 2016 Aug;26(8):869-85. doi: 10.1038/cr.2016.86. Epub 2016 Jul 22.

Authors

Ido Livneh¹, Victoria Cohen-Kaplan¹, Chen Cohen-Rosenzweig¹, Noa Avni¹, Aaron Ciechanover¹

Affiliation

¹ Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.

Abstract

The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Proteasome Endopeptidase Complex / chemistry
Proteasome Endopeptidase Complex / metabolism*
Protein Processing, Post-Translational
Proteolysis
Substrate Specificity

Substances

Proteasome Endopeptidase Complex
ATP dependent 26S protease