The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

Cell Res. 2016 Aug;26(8):869-85. doi: 10.1038/cr.2016.86. Epub 2016 Jul 22.


The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Proteasome Endopeptidase Complex / chemistry
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Processing, Post-Translational
  • Proteolysis
  • Substrate Specificity


  • Proteasome Endopeptidase Complex
  • ATP dependent 26S protease