Neurotherapeutic Strategies for Multiple Sclerosis

Neurol Clin. 2016 Aug;34(3):483-523. doi: 10.1016/j.ncl.2016.05.001.


Multiple sclerosis (MS) is the most common disabling neurologic disease of young adults. There are now 16 US Food and Drug Administration (FDA)-approved disease-modifying therapies for MS as well as a cohort of other agents commonly used in practice when conventional therapies prove inadequate. This article discusses approved FDA therapies as well as commonly used practice-based therapies for MS, as well as those therapies that can be used in patients attempting to become pregnant, or in patients with an established pregnancy, who require concomitant treatment secondary to recalcitrant disease activity.

Keywords: Adrenocorticotrophic hormone; Corticosteroids; Disease-modifying therapy; Exacerbation; MS; Multiple sclerosis; Pregnancy.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / therapy
  • Pregnancy